Relationship between PD-L1 expression and clinical and imaging features in patients with non-small cell lung cancer

ObjectiveTo explore the relationship between the programmed cell death ligand-1(PD-L1) expression in the tissues of non-small cell lung cancer(NSCLC) and clinical and chest imaging features.

MethodsThe clinical features and chest imaging features of 187 NSCLC patients who received PD-L1 detection were retrospectively analyzed.According to the expression of PD-L1, the patients were divided into the high expression group(40 cases), low expression group(65 cases) and negative group (82 cases), and the high expression group and low expression group were regarded as the positive group.The relationship between PD-L1 expression and clinical and imaging features were analyzed and compared among three groups.

ResultsThere was no statistical significance in gender, age, smoking history and pathological type among three groups(P>0.05), but there was statistical significance in TNM staging(P < 0.01).The chest CT findings showed that the who patients with lobulation, tracheobronchial invasion, burr sign and pleural effusion in high expression group were more than those in low expression group(P < 0.05 to P < 0.01).The differences of the pulmonary fibrosis, lesions close to the pleura, pleural pull sign, pleural thickening, multiple nodules and burr sign in the positive group were statistically significant(P < 0.05 to P < 0.01).

ConclusionsThe TNM staging and imaging features of NSCLC patients with different PD-L1 expressions show the differences in pleural traction sign, pleural thickening, burr sign, multiple nodules, fibrosis, and pleural proximal manifestations.