Predictive risk factors of serum E2 and AMH levels for pregnancy failure in patients with diminished ovarian reserve undergoing IVF-ET

ObjectiveTo explore the predictive value of serum estradiol (E2) and anti-müllerian hormone (AMH) for pregnancy failure risk in vitro fertilization-embryo transfer (IVF-ET) patients diagnosed with diminished ovarian reserve (DOR).

MethodsA total of 86 DOR patients with IVF-ET pregnancy were enrolled in this study.According to pregnancy outcomes, they were divided into non-pregnancy group (n=40) and pregnancy group (n=46).The baseline data and pregnancy outcomes were comparel between two groups.Univariate and multivariate logisitic regression analysis and ROC curve analysis were used to evaluate the value of serum E2 and AMH in predicting pregnancy failure risk.

ResultsIn non-pregnancy group, the incidence of FSH/LH ≥ 1.8, the number of antral follicle less than 5, the number of retrieved oocytes less than 8, serum AMH lower than 0.6 ng/mL and serum E2 lower than 34.06 pg/mL were higher than those in pregnancy group(P < 0.01).And the factors such as FSH/LH ≥ 1.8, serum AMH lower than 0.6 ng/mL and serum E2 lower than 34.06 pg/mL were independent risk factors for pregnancy failure in DOR patients (P < 0.05 to P < 0.01).In the meanwhile, the area under the ROC curve of serum AMH combined with E2 in predicting IVF-ET pregnancy failure was significantly higher than that with AMH and E2 alone (P < 0.01).The cutoff values of serum AMH and E2 in predicting IVF-ET pregnancy failure were 0.609 ng/mL and 31.63 pg/mL, respectively.

ConclusionsFor DOR patients, the levels of serum AMH and E2 can be used to predict the risk of IVF-ET pregnancy failure.And the combination of serum AMH and E2 has a better evaluation value in predicting the pregnancy outcome of DOR patients.