Effect of early ultrasound-guided abdominal puncture and drainage on intestinal bacterial translocation and cytokines in patients with severe acute pancreatitis

ObjectiveTo investigate the effects of early ultrasound-guided abdominal puncture and drainage on intestinal bacterial translocation and inflammatory mediators in patients with severe acute pancreatitis(SAP).

MethodsOne hundred SAP patients were selected as the research objects.According to the time from onset to admission, the SAP patients were divided into the observation group(within 48 hours from onset to admission) and control group(more than 48 hours from onset to admission)(50 cases in each group).Two groups were treated with ultrasound-guided abdominal puncture and drainage.The number of intestinal flora(including lactobacilli, bifidobacteria, staphylococci and Escherichia coli) and serum levels of interleukin(IL)-6, tumor necrosis factor-α(TNF-α), IL-4 and IL-10 were compared between two groups.

ResultsCompared with the control group, the number of pathogenic Escherichia coli and Staphylococci were significantly reduced, and the number of beneficial bacteria(lactobacilli and bifidobacteriza) significantly increased in the observation group after treatment(P<0.01).Compared with the control group, the serum levels of IL-6 and TNF-α significantly decreased, and the serum levels of IL-4 and IL-10 significantly increased in the observation group after treatment(P<0.01).

ConclusionsThe early ultrasound-guided abdominal puncture and drainage can reduce the intestinal bacterial translocation and inflammatory response in SAP patients.