Correlation analysis of the body mass gain and blood lipid level during pregnancy with target organ damage of pregnancy hypertension and pregnancy outcome

ObjectiveTo explore the correlation of the body mass gain and blood lipid level during pregnancy with target organ damage of pregnancy hypertension and pregnancy outcome.

MethodsA total of 85 pregnant women with hypertension during pregnancy were set as the study group, and 60 normal pregnant women during the same period were randomly selected as the control group.The general data of two groups were statistically compared, and the risk factors of hypertension during pregnancy were investigated.The body mass gain and blood lipid level during pregnancy of patients with different target organ damage in study group were compared, and the correlation between the body mass gain, blood lipid level during pregnancy and target organ damage were analyzed.The study group was followed up to the end of pregnancy, and the pregnancy outcome of the study group was counted.The baody mass gain and blood lipid level during pregnancy were compared between patients with good and poor pregnancy outcomes and the efficacy of body mass gain and blood lipid level during pregnancy in assessing target organ damage and predicting poor pregnancy outcome were explored.

ResultsBefore pregnancy, the body mass index(BMI), body mass gain during pregnancy, family history of hypertension, and levels of triglyceride(TG), total cholesterol(TC) and low-density lipoprotein cholesterol(LDL-C) in study group were higher than those in control group(P<0.01), and the high-density lipoprotein cholesterol(HDL-C) level in study group was lower than that in control group(P<0.05).The BMI before pregnancy, body mass gain during pregnancy, family history of hypertension, and levels of TG, TC, HDL-C and LDL-C were the influencing factors of hypertension during pregnancy(P<0.05 to P<0.01).The body mass gain during pregnancy, and levels of TG, TC and LDL-C were positively correlated with the target organ damage(P<0.01), and the HDL-C level was negatively correlated with target organ damage(P<0.05).The area under the curve (AUC) of body mass gain during pregnancy, and levels of TG, TC, HDL-C and LDL-C in the combined assessment of target organ damage was 0.879, which was greater than a single assessment of each index, and the best evaluation sensitivity and specificity were 73.82% and 92.40%, respectively.The body mass gain during pregnancy, and levels of TG, TC and LDL-C in patients with poor pregnancy outcome were higher than those in patients with good pregnancy outcome(P<0.05), and the HDL-C level in patients with poor pregnancy outcome was lower than that in patients with good pregnancy outcome(P<0.05).The AUC of body mass gain during pregnancy, and levels of TG, TC, HDL-C and LDL-C in the combined assessment of poor pregnancy outcome was 0.932, which was greater than a single assessment of each index, and the best evaluation sensitivity and specificity were 88.89% and 88.06%, respectively.

ConclusionsThe body mass gain and blood lipid level during pregnancy are closely related to the onset of pregnancy-induced hypertension and target organ damage, and can assist the clinical assessment of target organ damage and predict the risk of adverse pregnancy outcome.