Correlation analysis of the levels of HbA1c and 2 hPG with degree of coronary artery disease in CHD patients

ObjectiveTo analyze the correlation between the levels of glycosylated hemoglobin(HbA1c), 2-hour postprandial blood glucose(2hPG) and degree of coronary artery disease in patients with coronary atherosclerotic heart disease(CHD).

MethodsA total of 80 patients with CHD were set as the observation group, and divided into the mild disease group(26 cases), moderate disease group(38 cases) and severe disease group(16 cases) according to the Gensini score.During the same period, 80 patients with normal coronary angiography(CAG) were set as the control group.The metabolic indexes between the observation group and control group were compared, and the levels of HbA1c and 2hPG among the CHD patients with different degrees of coronary lesions were compared.The correlation between HbA1c and 2hPG in patients with CHD was analyzed.The correlation between the levels of HbA1c and 2hPG, and between the levels of HbA1c, 2hPG and severity of CHD disease were analyzed.

ResultsThe serum levels of HbA1c and 2hPG in observation group were significantly higher than those in control group(P<0.01).The levels of HbA1c and 2hPG gradually increased with the aggravation of severity of coronary artery lesions in CHD patients(P<0.01).There was a significant positive correlation between HbA1c level and 2hPG level in CHD patients(r=0.332, P<0.01).There was a significant positive correlation between the degree of coronary lesions and levels of HbA1c, 2hPG in CHD patients(r_s=0.546, P<0.01;r_s=0.437, P<0.01).

ConclusionsThe levels of HbA1c and 2hPG in patients with CHD significantly increase, which is significantly positively correlated with degree of coronary lesions.