Study on the correlation between serum level of cystatin C and severity of white matter lesions

ObjectiveTo explore the correlation between serum cystatin C(CysC) level and severity of white matter lesions(WMLs).

MethodsOne hundred and twenty-three WMLs patients confirmed by MRI were divided into the mild, moderate and severe groups according to the Fazekas scale, and the serum levels of CysC and other clinical indicators in all cases were collected.The risk factors of WMLs were analyzed using logistic regression analysis, and the correlation between CysC level and WMLs severity were analyzed among three groups.

ResultsThe level of CysC in severe group was significantly higher than that in mild and moderate groups(P < 0.01).The results of multivariate logistic regression analysis showed that the older age, hypertension and high serum CysC level were all independent risk factors of WMLs(P < 0.05 to P < 0.01).The results of Spearman correlation analysis revealed that the CysC level was positively correlated with the severity of WMLs(r=0.410, P < 0.05).

ConclusionsThe serum level of CysC is closely related to the severity of WMLs.