Relationship between the serum level of cyclophilin A and severity of coronary artery disease in patients with coronary heart disease

ObjectiveTo study the relationship between the serum level of cyclophilin A(CyPA) and severity of coronary artery disease in patients with coronary heart disease(CHD).

MethodsA total of 121 patients with CHD diagnosed by coronary angiography were divided into the single-vessel lesion group, double-vessel lesion group and multiple-vessel lesion group according to the results of coronary angiography, and the patients were divided into the mild lesion group(Gensini score ≤ 30 points), moderate lesion group(Gensini score 30-60 points) and severe lesion group(Gensini score ≥ 60 points) according to the Gensini score.The serum levels of CyPA, matrix metalloproteinase-9(MMP-9) and C-reactive protein(CRP) among three groups were compared.

ResultsWith the increasing of the number of coronary artery lesion, the levels of CyPA, MMP-9 and CRP in CHD patients increased(P < 0.05).With the increasing of Gensini score in coronary artery disease, the levels of CyPA, MMP-9 and CRP in CHD patients increased(P < 0.05).The serum level of CyPA was positively correlated with the MMP-9, CRP and Gensini coronary lesion score in CHD patients.

ConclusionsThe more the number of coronary lesion and higher the Gensini score of coronary lesions in CHD patient, the higher the CyPA level is.The CyPA can indirectly reflect the severity of coronary artery disease to some extent, and its mechanism may be involved in inflammatory response.