Study on the correlation between liver cirrhosis complicated with upper gastrointestinal bleeding and blood lipid levels

ObjectiveTo study the correlation between liver cirrhosis combined with upper gastrointestinal bleeding and blood lipid levels.

MethodsThe general data of 205 patients with liver cirrhosis were retrospectively analyzed, and the patients were divided into the observation group(liver cirrhosis combined with upper gastrointestinal bleeding, 82 cases) and control group(liver cirrhosis, 123 cases) according to with or without complicated with upper gastrointestinal bleeding.The general data and blood lipid levelstriglyceride(TG), total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were compared between two groups, and the ROC curve analysis was performed.The observation group was subdivided into the mild group and severe group according to the amount of upper gastrointestinal bleeding, and the correlation between blood lipid levels and disease severity was analyzed.

ResultsThere was no statistical significance in TG level between two groups(P>0.05), but the levels of TC, LDL-C and HDL-C in observation group were significantly lower than those in control group(P < 0.01).The area under the curve, sensitivity and specificity of the combined diagnosis were greater than those of the single index diagnosis.When TC ≤ 2.69 mmol/L, HDL-C ≤ 0.98 mmol/L, LDL-C ≤ 1.61 mmol/L, the probability of upper gastrointestinal bleeding in patients with liver cirrhosis would increase(P < 0.01).There was no statistical significance in TG level between two groups(P>0.05), but the levels of TC, LDL-C and HDL-C in mild group were significantly higher than those in severe group(P < 0.05 to P < 0.01).The results of Spearman correlation analysis showed that the TG level was not correlated with disease severity(P>0.05), while the levels of TC, LDL-C and HDL-C were negatively correlated with the disease severity(P < 0.05).

ConclusionsThe blood lipid levels in patients with liver cirrhosis complicated with upper gastrointestinal bleeding significantly decrease, and all are negatively correlated with the severity of bleeding, which can be used as a predictive factor of upper gastrointestinal bleeding in patients with liver cirrhosis.