Value of risk calculator and neutrophil/lymphocyte ratio in the prediction of neonatal early-onset sepsis

ObjectiveTo investigate the value of risk calculator and neutrophil/lymphocyte ratio(NLR) in the prediction of the neonatal early-onset sepsis(EOS).

MethodsThe clinical and laboratory data of 43 patients diagnosed by EOS(sepis group) and 43 hospitalized patients with non-infectious diseases(control group) were retrospectivly analyzed.The risk of EOS was assessed using the sepsis risk calculator, and the diagnostic efficacy of the sepsis risk calculator and NLR were assessed using the receiver operating characteristic(ROC) curve.

ResultsThe NLR value in the sepsis group and control group was(3.89±3.11) and (1.82±0.73), respectively, and the difference of which between two groups was statistical significant(P < 0.01).The incidence risk coefficient per thousand children in the sepsis group and control group was(4.03±10.31) and (0.02±0.06), respectively, and the difference of which between two groups was statistical significan(P < 0.05).The area under the curve, diagnostic sensitivity and specificity of the risk calculator, NLR and their combination were (0.857, 0.710 and 0.910, respectively), (74.4%, 62.8% and 83.7%, respectively) and (97.7%, 90.7% and 97.7%, respectively), respectively.The diagnostic efficiency of the risk calculator combined with NLR was higher than that of NLR alone(P < 0.01).

ConclusionsBoth the sepsis risk calculator and NLR have high predictive value for EOS, and the combination of the two is helpful for the early diagnosis and treatment of EOS.