Study on the relationship between post-stroke depression and blood lipid level

ObjectiveTo explore the relationship between post-stroke depression(PSD) and blood lipid level, and provide the guidance for clinical intervention of stroke.

MethodsTwo hundred patients with stroke were randomly selected, and divided into the PSD group(88 cases) and non-PSD group(112 cases) according to the occurrence of PSD.The serum levels of triglyceride(TG), total cholesterol(TC), high density lipoprotein(HDL-C) and low density lipoprotein(LDL-C) in two groups were detected, and compared between two groups.The correlation among clinical indicators and depression score of stroke patients were analyzed.

ResultsThe serum level of HDL-C in PSD group was significantly higher than that in non-PSD group(P < 0.01), and the differences of the levels of TG, TC and LDL-C between two groups were not statistically significant(P>0.05).The HAMD and HAMA scores were positively correlated with the NIHSS scores, stroke times, TC and HDL-C levels(P < 0.05 to P < 0.01), and negatively correlated with the ADL score(P < 0.01).The ADL score and HDL-C level were the independent influencing factors of HAMD score in stroke patients(P < 0.01).

ConclusionsThe abnormal lipid metabolism is associated with PSD to a certain extent.In the course of lipid regulation therapy for stroke patients, the occurrence of PSD should be vigilant, and the PSD should be identified and intervened as early as possible in order to improve the prognosis of stroke.