Observation on the analgesic effect of transversus abdominis plane block with combination of dexmedetomidine and ropivacaine after radical resection of colorectal cancer

ObjectiveTo investigate the analgesic effect of transversus abdominis plane block with combination of dexmedetomidine and ropivacaine after radical resection of colorectal cancer.

MethodsSixty patients undergoing elective open radical resection of colorectal cancer were randomly divided into general anesthesia group(group G), ropivacaine combined with general anesthesia group(group R+G) and dexmedetomidine combined with ropivacaine group(group DR+G), 20 cases in each group.Group G was given general anesthesia, group R+G was given general anesthesia combined with transversus abdominis plane block on both sides separately using 20 mL 0.25% ropivacaine, and group DR+G was given general anesthesia combined with transversus abdominis plane block on both sides separately using 20 mL 1 μg/kg dexmedetomidine and 0.25% ropivacaine.All patients received sufentanil via patient-controlled introvenous analgesia after operation.The operation time, intraoperative infusion volume, the dosage of propofol and remifentanil, and the dosage of sufentanil 24 h after operation in three groups were observed.The resting visual analog scale(VAS) score and cough VAS score were compared at 2 h(T₁), 6 h(T₂), 12 h(T₃), 24 h(T₄) after operation, and the adverse reactions were recorded.

ResultsThere were significant differences in the dosage of propofol, remifentanil and sufentanil among the three groups(P < 0.05 to P < 0.01);the dosage of propofol and remifentanil in group DR+G was lower than that in group G(P < 0.05);the dosage of sufentanil in group DR+G, group R+G and group G increased gradually, and the difference of which was statistically significant(P < 0.05 to P < 0.01).At T₁, T₂ and T₃, there was no significant difference in the resting VAS score and cough VAS score among the three groups(P>0.05);at T₄, the resting VAS score and cough VAS score in group DR+G were lower than those in group R+G and group G(P < 0.05 to P < 0.01).The incidence of skin itching, nausea and vomiting in group DR+G was lower than that in group G(P < 0.05).

ConclusionsTransversus abdominis plane block with combination of dexmedetomidine and ropivacaine can reduce the dosage of general anesthesia during and after operation, improve the analgesic effect after radical resection of colorectal cancer, relieve pain and reduce adverse reactions.