Study on the correlation between the levels of CHE, GGT and LDH, and severity of hypertensive disorder complicating pregnancy patients

ObjectiveTo investigate the changes of serum levels of cholinesterase(CHE), γ-glutamyl transpeptidase(GGT) and lactate dehydrogenase(LDH) expression in patients with hypertensive disorder complicating pregnangcy(HDCP), and their correlation with the degree of disease.

MethodsEighty patients with HDCP were selected, and divided into the severe preeclampsia group(21 cases), non-severe preeclampsia group(34 cases) and simple HDCP group(25 cases) according to the progress of HDCP, and 68 normal pregnant women in the same period were selected as the control group.The serum levels of CHE, GGT and LDH in four groups were measured and compared.The relationship between the serum indicators, and levels of SBP and DBP, occurrence of preeclampsia in HDCP patients were analyzed, and the value of serum indexes in predicting adverse pregnancy outcome in HDCP patients was investigated.

ResultsThe levels of SBP and DBP in the severe preeclampsia group, non-severe preeclampsia group, HDCP group and control group gradually decreased in turn(P < 0.05 to P < 0.01).The levels of CHE in the severe preeclampsia group, non-severe preeclampsia group, HDCP group and control group gradually increased in turn(P < 0.05 to P < 0.01).The levels of GGT and LDH in severe preeclampsia group, non-severe preeclampsia group, HDCP group and control group gradually decreased in turn(P < 0.05 to P < 0.01).The serum levels of CHE in HDCP patients was negatively correlated with the levels of SBP and DBP(P < 0.01), and the serum levels of GGT and LDH were positively correlated with the levels of SBP and DBP(P < 0.01).After controlling the age, prepregnancy body weight, gestational age and maternal type, the serum level of CHE was negatively correlated with the onset of preeclampsia(P < 0.01), and the levels of GGT and LDH were positively correlated with the onset of preeclampsia(P < 0.01).During follow-up to delivery, the expression of CHE in HDCP patients with adverse pregnancy outcome was lower than that in HDCP patients without adverse pregnancy outcome(P < 0.01), while the expression of GGT and LDH in HDCP patients with adverse pregnancy outcome were higher than that in HDCP patients without adverse pregnancy outcome(P < 0.01).The best cutoff values of CHE, GGT and LDH in predicting adverse pregnancy outcomes in HDCP patients were ≤ 2.83 kU/L, >32.16 U/L and>256.06 IU/L, respectively, and the areas under the curve were smaller than that in combined prediction.

ConclusionsThe abnormal expression of serum CHE, GGT and LDH is an important influencing factor for the occurrence of preeclampsia, has a certain correlation with the degree of illness in HDCP patients, and the combination of the three is better in predicting adverse pregnancy outcomes in patients with HDCP.