Effect of CT-guided Hook-wire positioning assisted thoracoscopic surgery in the treatment of early NSCLC, and its influence on serum tumor markers and postoperative recurrence

ObjectiveTo investigate the effects of CT-guided Hook-wire positioning assisted thoracoscopic surgery in the treatment of early non-small cell lung cancer(NSCLC), and its influence on the serum tumor markers and postoperative recurrence.

MethodsNinety-eight patients with early NSCLC were selected, and divided into the observation group and control group according to the random number table method(49 cases each group).The observation group were treated with CT-guided Hook-wire positioning assisted thoracoscopic surgery, and the control group were treated with thoracoscopic surgery.The operation status, serum tumor marker indicatorscytokeratin 19, fragment antigen 21-1(CYFRA21-1), carcinoembryonic antigen(CEA) and carbohydrate antigen 50(CA50) and lung function indexesforced vital capacity(FVC), maximum ventilation(MVV), forced expiratory volume in the first second(FEV1) before and afteroperation, and complications were compared between two groups.All patients were followed up for 12 months, and the recurrence rates in two groups were counted.

ResultsThe intraoperative blood loss, postoperative drainage, thoracic catheter drainage time and hospitalization time in observation group were significantly less than those in control group(P < 0.01).After 1 d of operation, the serum levels of CEA, CYFRA21-1 and CA50 in two groups decreased compared with those before surgery(P < 0.05), but there was no statistical significance between two groups(P>0.05).After 2 weeks and 1 month of operation, the MVV, FVC and FEV1 in two groups decreased compared with those before operation(P < 0.05), but which in observation group was significantly higher than that in control group(P < 0.01).The incidence rates of complications in the observation group and control group were 6.12%(3/49) and 10.20%(5/49), respectively, and the difference of which was not statistically significant(P>0.05).After 12 months of surgery, the recurrence rate of disease in observation group2.04%(1/49) was lower than that in control group14.29% (7/49) (P < 0.05).

ConclusionsThe use of CT-guided Hook-wire positioning assisted thoracoscopic surgery in the treatment of early NSCLC is accurate, little damage to lung function, quick recovery, and can reduce the risk of disease recurrence.