Analysis of correlation between lactate level and blood glucose, oxygenation indexes in low-month-old and low-weight children treated with cardiopulmonary bypass

ObjectiveTo analyze the correlation between lactate level and blood glucose, oxygenation index in low-month-old and low-weight congenital heart disease children treated with cardiopulmonary bypass.

MethodsOne hundred and twenty-nine congenital heart disease children treated with cardiopulmonary bypass were divided into the high lactate group(n=43) and normal lactate group(n=85) according to the lactate level after 6 h of surgery.The operation-related indexes, and levels of glucose, and oxygenation indexes were compared between two groups.The multivariate logistic regression model was used to analyze the influencing factors of lactate level in children after operation.The Pearson correlation model was used to analyze the correlation between lactate level and glucose, oxygenation index in children after 6 hours of operation.

ResultsThe extracorporeal circulation time, aortic occlusion time, glucose and lactate levels in high lactate group were higher than those in normal lactate group(P < 0.05 to P < 0.01).The differences of arterial oxygen saturation(SaO₂) and venous oxygen saturation(SvO₂) (SaO₂-SvO₂) levels and incidence rate of ketosis were not statistically significant between two groups(P>0.05).The results of multivariate logistic regression analysis showed that the older age was a protective factor to prevent the increasing of lactate level after cardiopulmonary bypass(P < 0.05), the extracorporeal circulation time, aortic occlusion time and high glucose level were the independent risk factors of the increasing of lactate level after cardiopulmonary bypass(P < 0.05 to P < 0.01).The results of Pearson correlation analysis showed that the lactate level was significantly positively correlated with glucose(P < 0.01), but had no significant correlation with(SaO₂-SvO₂) level(P>0.05).

ConclusionsThe lactate level in low-month-old and low-weight children after 6 h of cardiopulmonary bypass is correlated with the glucose level, but not with oxygen intake.