Study on the risk factors of carbapenem-resistant Klebsiella pneumoniae infection in adult inpatients

ObjectiveTo analyze the influencing factors of carbapenem-resistant Klebsiella pneumoniae(CRKP) infection in adult inpatients.

MethodsThe clinical data of adult inpatients infected with Klebsiella pneumoniae were collected.According to whether Klebsiella pneumoniae was resistant to carbapenem antibiotics, the patients were divided into the CRKP group and carbapene sensitive Klebsiella pneumoniae(CSKP) group.The influencing factors of CRKP infection were analyzed.

ResultsThe results of univariate analysis showed that the differences of CRKP infection in the admission to intensive care unit, use of carbapenem antibacterial drugs, use of ventilator and use of catheter were statistically significant(P < 0.01).The results of multivariate analysis showed that the admission to intensive care unit and use of ventilator were the independent risk factors of CRKP infection(P < 0.01).

ConclusionsIt is helpful to control the spread of CRKP by strengthening the monitoring of drug resistance in intensive care units, carrying out screening for colonization, standardizing the use of antibiotics, paying attention to aseptic operation and hand hygiene of medical staff, and strictly implementing disinfection and isolation measures.