Correlation analysis of preoperative inflammatory indicators and clinicopathological features in breast cancer patients

ObjectiveTo analyze the relationship between preoperative inflammatory indicators and clinicopathological features in patients with breast cancer.

MethodsA total of 49 breast cancer patients treated with mastectomy and 48 benign proliferative breast disease patients treated with quadrant resection were divided into the observation group and control group, respectively.The red blood cell distribution width(RDW), neutrophil to lymphocyte ratio(NLR), platelet to lymphocyte ratio(PLR) and systemic immune inflammation index(SII) were compared between two groups.The diagnostic value of RDW, NLR, PLR and SII in breast cancer were analyzed using receiver operating characteristic(ROC) curve, and the relationship between RDW, NLR, PLR and SII, and clinicopathologic features were analyzed.

ResultsThe levels of RDW, NLR, PLR and SII in observation group were higher than those in control group(P < 0.05 to P < 0.01).The results of ROC curve analysis showed that the AUC of RDW, NL and SII were higher than that of PLR(P < 0.05), and the differences of the AUC between RDW and NLR, SII were not statistically significant(P>0.05).According to the optimal cut-off value, when the RDW was higher than 12.89%, the sensitivity and specificity of which were 79.6% and 91.7%, respectively.When the NLR was higher than 1.78, the sensitivity and specificity of which were 69.4% and 9.6%, respectively.When the PLR was higher than 143.57, the sensitivity and specificity of which were 34.7% and 97.9%, respectively.When the SII was higher than 392.42, the sensitivity and specificity of which were 65.3% and 91.7%, respectively.The NLR and PLR were correlated with the axillary lymph node metastasis(P < 0.05 and P < 0.01), and the PLR was correlated with the clinical stage of breast cancer(P < 0.05).

ConclusionsThe levels of RDW, NLR, PLR and SII in breast cancer patients are high, which has some auxiliary diagnostic value for breast cancer.The NLR is associated with axillary lymph node metastasis, and the PLR is associated with axillary lymph node metastasis and clinical stage of breast cancer.