Study on the clinical characteristics of hyperlipidemic acute pancreatitis and effects of triglyceride on the severity of disease

ObjectiveTo investigate the clinical features of hyperlipidemic acute pancreatitis(HLAP), and effects of triglyceride on the severity of disease.

MethodsThe clinical data of 68 patients with HLAP and 50 patients with biliary acute pancreatitis(BAP) were retrospectively analyzed.According to the TG level, the HLAP patients were divided into the TG increasing group(TG < 22.4 mmol/L) and severe TG increasing group(TG ≥ 22.4 mmol/L), and the combined disease and severity of disease were compared between two groups.

ResultsThe ratios of male, complicated with obesity, diabetes, fatty liver and relapse in HLAP group were significantly higher than those in BAP group(P < 0.05 to P < 0.01), and the age in HLAP group was lower than the BAP group(P < 0.05).There was no statistical significance in the proportion of SAP and length of hospital stay between two groups(P>0.05).The levels of TG, blood glucose(Glu), total cholesterol(TC) and uric acid(UA) in HLAP group were significantly higher than those in BAP group(P < 0.05), and the levels of blood calcium(Ca), alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL) and direct bilirubin(DBIL) in HLAP group were lower than those in BAP group(P < 0.05 to P < 0.01).There was no statistical significance in the ratios of age, combined obesity, diabetes, fatty liver, hypertension and recurrence between the TG increasing group and TG severe increasing group(P>0.05).There was no statistical significance in the TG level and severity of HLAP patients between two groups(P>0.05).

ConclusionsThe incidence of HLAP is more common in middle-aged men, which is easy to be combined with obesity, diabetes, fatty liver, relapse and serum calcium level decreasing.The serum level of TG significantly increases, and there was no significant correlation with the severity of disease in HLAP patients.