Influence of perioperative complications and prognosis in gastric cancer patients treated with radical gastrectomy

ObjectiveTo analyze the risk factors of perioperative complications in patients treated with radical gastrectomy and their effects on long-term prognosis.

MethodsThe clinical data of 106 patients treated with radical gastrectomy were analyzed, and the patients were divided into the perioperative complication group(27 cases) and no perioperative complication group(79 cases) according to the occurrence of perioperative complications The independent risk factors affecting the occurrence of complications were analyzed using multivariate logistic regression analysis, and the influence of perioperative complications on the long-term prognosis of patients were analyzed using Cox regression analysis.

ResultsThe incidence rate of perioperative complications in patients treated with gastric cancer radical was 25.47%(27/106), and there was no statistical significance in general information(gender, smoking and drinking) between two groups.The results of multivariate logistic regression analysis showed that the age ≥ 65, TNM staging and combined visceral resection(P < 0.01) were the independent risk factors of perioperative complications in patients treated with radical gastrectomy.A total of 98 patients(92.45%) were followed up for 22-86 months, and the 5-year survival rate was 39.80%.The 5-year survival rates of patients with and without perioperative complications were 60.37% and 32.00%, respectively, and the difference of which was statistically significant(P < 0.05).The results of multivariate Cox regression analysis showed that the tumor size, TNM staging, combined visceral resection and perioperative complications were the independent factors affecting the prognosis of patients treated with radical gastrectomy for gastric cancer(P < 0.05 to P < 0.01).

ConclusionsThe age, TNM staging and combined visceral resection are high risk factors of perioperative complications in patients with gastric cancer.The clinical measures should be taken to reduce the incidence of perioperative complications, so as to improve the postoperative quality of life and survival rate of patients.