Effect of Helicobacter pylori infection on metabolic levels in patients with type 2 diabetes mellitus

ObjectiveTo investigate the effect of Helicobacter pylori(HP) infection on metabolic levels in patients with type 2 diabetes mellitus (T2DM).

MethodsA total of 175 patients with T2DM were included in this study.These patients were divided into two groups as HP infection-positive or -negative.For each patient, the following data were collected or measured: age, gender and laboratory parameters including total cholesterol (TC), triglyceride(TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), lipoprotein-a (LP-a), fasting blood glucose (Glu) and glycosylated hemoglobin (HbA1c).The influence of HP infection on the metabolic levels of T2DM patients was analyzed by comparing the results between the two groups.

ResultsAmong 175 T2DM patients, 91 patients (52%) were HP positive and 84 patients (48%) were HP infection-negative.T2DM patients infected by HP showed significantly increased Lp-a and higher HbA1c than non-infected patients (P < 0.01).Additionally, 65.9% of the patients with HbA1c >8% were found to be HP positive, 55.6% of the patients with HbA1c ≤ 8% were HP positive.The levels of other parameters were not significantly different between two groups (P>0.05).

ConclusionsHP infection affects blood glucose and lipid metabolism in patients with T2DM, which may be involved in the occurrence and development of metabolic disorder associated diseases.