Early warning value analysis of early detection indicators of COVID-19 in critical disease

ObjectiveTo analyze the early warning value of early detection indicators of corona virus disease 2019(COVID-19) in critical disease.

MethodsThe patients with COVID-19 were divided into the critical group and non-critical group, and diabetic group and non-diabetic group.The levels of early blood glucose, neutrophils, C reactive protein, serum amyloid A, sialic acid, globulin, cystatin C, creatine kinase, creatine kinase isoenzyme, α-hydroxybutyrate dehydrogenase, lactate dehydrogenase, lactate dehydrogenation enzyme isozyme, serum albumin and other indicators were compared between the critical group and non-critical group, and between diabetic group and non-diabetic group.

ResultsThe differences of the gender and age between critical group and non-critical group were not statistically significant(P>0.05).The differences of the levels of neutrophils, serum amyloid A, sialic acid, creatine kinase isoenzyme, α-hydroxybutyrate dehydrogenase, lactate dehydrogenase, lactate dehydrogenase isoenzyme and serum albumin between critical group and non-critical group were statistically significant(P < 0.05 to P < 0.01), and there was no statistical significance in the levels of blood glucose, C reactive protein, globulin, cystatin C and creatine kinase between two groups(P>0.05).There was no statistical significance in the gender and age between the diabetic group and non-diabetic group(P>0.05), the differences of the levels of blood glucose and serum albumin between two groups were statistically significant(P < 0.01 and P < 0.05), and the differences of the levels of neutrophils, C-reactive protein, serum amyloid A, sialic acid, globulin, Cystatin C, creatine kinase, creatine kinase isoenzyme, α-hydroxybutyrate dehydrogenase, lactate dehydrogenase and lactate dehydrogenase isoenzyme between two groups were not statistically significant(P>0.05).

ConclusionsThe inerease of neutrophils, serum amyloid A, sialic acid of inflammatory indexes, creatine kinase isoenzyme, α-hydroxybutyrate dehydrogenase, lactate dehydrogenase, lactate dehydrogenase isoenzyme and decrease of the albumin are the early predictors of critical disease.The decrease of nutritional status caused by hyperglycemia has an important impact on the severity of COVID-19.