Effect of Solitaire AB stent thrombus removal combined with butylphthalide on serum HCY, PLGF, NIHSS scores and mRS scores in patients with acute anterior circulation large vessel occlusive stroke

Objective To explore the effects of Solitaire AB stent thrombus removal combined with butylphthalide sodium chloride injection on serum HCY, PLGF, NIHSS score and mRS score in patients with acute anterior circulation large vessel occlusive stroke.

Methods A total of 120 patients with acute anterior circulation cerebral infarction were selected as the experimental subjects of the study.The patients were divided into the control group and observation group by random number table method, with 60 cases in each group.Patients in the control group were treated with Solitaire AB stent thrombus removal.Patients in the observation group were given butylphthalide sodium chloride injection on the basis of the control group.Serum HCY, PLGF and NIHSS score and mRS score were compared between the two groups.

Results Before treatment, there was no significant difference in the clinical pathological data of the two groups of patients and the comparison of various indicators in this study.After treatment, the serum HCY level in the observation group immediately after surgery was(17.35±5.01) μmol/L, the level of HCY on the 14th day after operation was (13.79±3.13) μmol/L, the immediate level of HCY in the control group was(21.54±4.95) μmol/L and the level of HCY on the 14th day after operation was(16.65±4.23) μmol/L.The improvement of the observation group was significantly better than that of the control group (P < 0.01).The PLGF level of patients in the observation group was(79.28±9.13) ng/L at 14 days after operation.The PLGF level in the observation group was(62.35±7.26) ng/L, and the PLGF level in the observation group was significantly better than that of the control group.The NIHSS score and mRS score in the two groups were decreased(P < 0.01).After 14 days of treatment, the NIHSS score in the control group was(17.52±3.37), which was higher than that in the observation group(13.28±3.19) (P < 0.01).The proportion of patients with mRS score ≤ 2 in the control group was 28.33%, which was lower than 68.33% in the observation group(P < 0.01).

Conclusions Solitaire AB stent thrombus removal combined with butylphthalide sodium chloride injection can effectively increase the serum HCY expression level and reduce the PLGF level, the patient's NIHSS and mRS scores in patients with acute anterior circulation large vessel occlusive stroke, which can improve the clinical efficacy.