Objective To explore the relationship of serum uric acid and ambulatory blood pressure in patients with primary hypertension.
Methods The 24-hour ambulatory blood pressure in 61 elderly patients with primary hypertension was monitored, and the serum levels of uric acid were detected.According to the median level of serum uric acid, the patients were divided into the normal uric acid group(NUA group) and high uric acid group(HUA group).The 24 h average systolic and diastolic blood pressure(24hSBP and 24hDBP), daytime average systolic and diastolic blood pressure(dSBP and dDBP), nighttime average systolic and diastolic blood pressure(nSBP and nDBP) and blood pressure variability(BPV)including 24-hour systolic blood pressure standard deviation(24hSBPSD) and 24-hour diastolic blood pressure standard deviation(24hDBPSD) were compared between two groups.The correlation between serum uric acid level and blood pressure indexes was analyzed.According to 24hSBP, the patients were devided into the group with good blood pressure control and the group with poor blood pressure control, and the differences of serum uric acid level and ambulatory blood pressure parameters between the two groups were compared.
Results The 24hSBP, dSBP and SBPSD in HUA group were higher than those in NUA group(P < 0.05), and significantly positively correlated with the serum uric acid level(P < 0.05 to P < 0.01).The uric acid level in the group with good blood pressure control was lower than that in the group with poor blood pressure control(P < 0.01).The levels of SBP, dSBP and nSBP in the group with good blood pressure control were lower than those in the group with poor blood pressure control(P < 0.01).
Conclusions With the increasing of the level of serum uric acid in patients with primary hypertension, the systolic blood pressure and BPV increase.Monitoring the serum uric acid has important clinical significance in the prevention of hypertension.
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