Objective To study the effects of in vitro fertilization-embryo transfer(IVF-ET) unilateral salpingectomy on the serum levels of anti-Müllerian hormone(AMH) and ovarian function.
Methods A total of 200 patients with IVF-ET were divided into group A(70 cases treated with bilateral resection), group B(70 cases treated with unilateral resection), and group C(60 cases without resection) according to the method of salpingectomy.The AMH level and ovarian function on injection day, bilateral ovarian sinus follicles(AFC), use time and dosage of gonadotropin(Gn), number of eggs taken, effective embryos, high-quality embryos, total number of pregnancy, abortion, premature delivery and term delivery were compared among the three groups.
Results The levels of AMH, luteinizing hormone and estradiol in group A were significantly lower than those in group B and group C, the levels of follicle stimulating hormone and progesterone in group A were significantly higher than those in group B and group C, and the AMH level in group B was significantly lower than that in group C(P < 0.05 to P < 0.01).The bilateral AFC in group A was significantly lower than that in group B and group C, the Gn dosage in group A was significantly higher than that in group B and group C, and the Gn dosage in group B was significantly higher than that in group C(P < 0.05 to P < 0.01).There was no statistical significance in the number of eggs taken among the three groups(P>0.05).The number of effective embryos and high-quality embryos in group A were significantly lower than that in group B and group C (P < 0.05).The abortion rate in group A was significantly higher than that in group C, and the rate of full-term delivery in group A was significantly lower than that in group B and group C(P < 0.05 to P < 0.01).
Conclusions The IVF-ET unilateral salpingectomy can have a certain impact on the AMH level and ovarian function, but there was no significant change in pregnancy outcome.
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