ObjectiveTo investigate the expression level change of tissue plasminogen activator-inhibitor complex(t-PAIC) in patients with coronary heart disease(CHD), and its correlation with prognosis.
MethodsOne hundeed and eighty patients with CHD, which included 107 cases with unstable angina pectoris and 73 cases with stable angina pectoris, were set as the CHD group, and 60 patients without CHD were as the control group.The serum levels of creatine kinase isoenzyme(CKMB), total cholesterol(TC), C reactive protein(CRP), fasting blood glucose(FBG), plasminogen activator inhibitor 1(PAI-1) and tissue plasminogen activators(t-PA) were observed in two groups.The three, double and single-vessel lesions in CHD group, and levels change of PAI-1 and t-PA in control group were analyzed.
ResultsThe serum levels of TC, CRP, FBG, CKMB and PAI-1 in unstable angina pectoris patients of CHD group were significantly higher than those in stable angina pectoris pateints of CHD group and control group(P < 0.05), and the serum level of t-PA in unstable angina pectoris of CHD group was lower than that in stable angina pectoris pateints of CHD group and control group(P < 0.05 to P < 0.01).The serum levels of TC, CRP, FBG, CKMB and PAI-1 in stable angina pectoris patients of CHD group were higher than those in control group(P < 0.05 to P < 0.01).The serum levels of PAI-1 and t-PA in the three-vessel lesion group, double-vessel lesion group, single-vessel lesion group and control group decreased in turn, respectively, and the differences of which were statistically significant(P < 0.01).
ConclusionsThe t-PA level is correlated with the severity of CHA and number of coronary artery stenosis.The more severe the disease and more coronary stenosis are, the higher the level of PAI-1 and lower the level of t-PA are.The disease development of patients with CHD can be predicted through the detection of t-PA.
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