Therapeutic effect study of acoustic power target drug delivery combined with HRZES regimen in the retreatment of cavitary pulmonary tuberculosis

ObjectiveTo study the clinical effect of acoustic power target drug delivery combined with HRZES regimen on the retreatment of cavitary pulmonary tuberculosis.

MethodsEighty patients with recurrent cavitary pulmonary tuberculosis were divided into two groups by the random number table method, with 40 cases in each group.The control group was treated with HRZES.The observation group was treated with acoustic power target drug delivery based on HRZES.Lesion absorption, cavity closure, sputum negative conversion and complications at 2, 4 and 8 months after treatment were compared.

ResultsThe lesion absorption rate, cavity closure efficiency and sputum conversion rate in the observation group were significantly higher than those in the control group at 2, 4, and 8 months(P < 0.05).There was no significant difference in adverse reaction rate between the two groups(P>0.05).

ConclusionsAcoustic power target drug delivery combined with HRZES regimen for retreatment of cavitary pulmonary tuberculosis is safe and effective, which can promote the cavity shrinkage, sputum negative conversion and lesion absorption without increasing adverse reactions.