Study on the influencing factors of hemorrhage after ESD for early gastric cancer and precancerous lesions

ObjectiveTo study the influencing factors of hemorrhage after endoscopic submucosal dissection(ESD) for early gastric cancer and precancerous lesions.

MethodsEighty-six patients with early gastric cancer and precancerous lesions treated with ESD from January 2017 to September 2019 were investigated.All patients were treated with ESD.The occurrence of hemorrhage in patients with early gastric cancer and precancerous lesions after ESD were observed, and the general data and laboratory examination indexes of patients were counted.The independent influencing factors of hemorrhage in patients with early gastric cancer and precancerous lesions after ESD were analyzed using multivariate logistic regression analysis.

ResultsAmong the 86 patients treated with ESD, 16 patients, accounting for 18.60%, experienced hemorrhage.There was no hemorrhage in 70 patients, accounting for 81.40%.The results of multivariate logistic regression analysis showed that the lesion location for cardia-gastric fundus(OR=3.714, 95% CI=1.252-10.909), tumor size ≥ 3 cm(OR=3.802, 95% CI=1.538-9.646), and early cancer(OR=2.746, 95% CI=1.133-6.867) were the independent risk factors of hemorrhage after ESD for early gastric cancer and precancerous lesions(P < 0.05 to P < 0.01).

ConclusionsThe hemorrhage of patients with early gastric cancer and precancerous lesions after ESD is related to the location, size and pathological type of the lesion.The larger tumors, lesions locating in the cardia-gastric fundus and early gastric cancer are more prone to hemorrhage during treatment.