Effect of the preemptive analgesia timing of flubiprofen axetil and celecoxib on restlessness and postoperative analgesia in orthopedic general anesthesia patients

ObjectiveTo investigate the effects of the preemptive analgesia timing of flubiprofen axetil and celecoxib on restlessness and postoperative analgesia in orthopedic general anesthesia patients.

MethodsThree hundred and five patients treated with orthopaedic surgery under general anesthesia were randomly divided into the FE1, FE2, CE1, CE2 and C groups(61 cases in each group).The FE1 group was treated with 1 mg/kg of flubiprofen axetil before 30 min of operation, and the FE2 group was treated with 1 mg/kg of flubiprofen axetil before 15 min of operation.The CE1 group was given 200 mg celecoxib before 12 h and 1 h of operation, respectively.The CE2 group was given 200 mg celecoxib before 3 d of operation, once every 12 h, and the C group was not given flurbiprofen axetil or celecoxib before operation.The agitation score(RS) before extubation, visual analog pain score(VAS) after 1, 3, 6, 12 and 24 h of operation, and incidence rate of adverse reactions were compared among five groups.

ResultsThe differences of the RS scores of extubation among five groups were statistically significant(P < 0.01).The RS score of extubation in C group was significantly higher than that in FE1, FE2, CE1 and CE2 groups(P < 0.01), while there was no statistical significance among FE1, FE2, CE1 and CE2 groups(P>0.05).The VAS scores in C group after 1, 3, 6, 12 and 24 h of surgery were significantly higher than that in other 4 groups(P < 0.01), and the VAS score in C group after 24 h of surgery was significantly higher than that in CE1 and CE2 groups(P < 0.01).At 1 and 3 h after operation, the VAS scores in FE1, FE2 and CE2 groups were significantly lower than that in CE1 group(P < 0.01).After 12 h of surgery, the VAS scores in FE1 group and FE2 group were significantly higher than that in CE2 group(P < 0.01).After 24 h of surgery, the VAS scores in FE1 and FE2 groups were significantly higher than those in CE2 and CE1 groups(P < 0.01).There was no statistical significance in the incidence rate of adverse reactions among five groups(P>0.05).

ConclusionsThe continuous administration of celecoxib before 3 days of operation has good effects on short-term and medium- and long-term analgesia, does not increase the adverse reactions, and has good safety, so it is worth popularizing and applying in clinic.