Prediction of neutrophil to lymphocyte ratio on prognosis of patients with acute myocardial infarction combined with multi-vessel disease

ObjectiveTo analyze the predictive value of neutrophil to lymphocyte ratio(NLR) on prognosis of patients with acute myocardial infarction(AMI) combined multi-vessel disease(MVD).

MethodsA total of 216 cases of AMI combined with MVD with complete clinical data were included.Patients were divided into high NLR group(60 cases) and low NLR group(156 cases) according to the optimal cut-off value of admission NLR to predict 2-year all-cause mortality.The predictive effect of NLR on the long-term prognosis of AMI patients combined with MVD was analyzed by Cox regression analysis.

ResultsThe results of ROC curve showed that the cut-off point value of 2-year all-cause mortality predicted by NLR was 3.65.Compared with patients in the low NLR group, patients in the high NLR group were older and had a higher incidence of hypertension(P < 0.05), and the white blood cell count, neutrophil count and high sensitivity C reactive protein were higher, and the lymphocyte count was lower(P < 0.01).The results of multivariate Cox risk regression analysis showed that NLR, hypertension and neutrophil count were the independent factors affecting all-cause mortality in AMI patients combined with MVD(P < 0.05 to P < 0.01), and NLR and neutrophil count were independent factors affecting the occurrence of MACCE(P < 0.05 and P < 0.01).

ConclusionsThe cut-off point value of NLR predicting 2-year all-cause mortality is 3.65.NLR is an independent factor affecting the prognosis of AMI patients combined with MVD.