Expression of BTG1 in non-small cell lung cancer and its relationship with prognosis

ObjectiveTo investigate the expression of B-cell translocation gene 1 (BTG1) in non-small cell lung cancer(NSCLC) tissue and its correlation with prognosis.

MethodsImmunohistochemical method was applied to detect the level of BTG1 protein expression in patients with different clinical pathological parameters of NSCLC.The survival curve was plotted to analyze the relationship between BTG1 and the patient's 5-year survival rate.

ResultsThe positive rate of BTG1 protein expression was 38.4% in NSCLC tissues, the lymph node metastasis, clinic stage and histological grade in positive and negative group of BTG1 protein expression were statistically significant(P < 0.05 to P < 0.01).The 5-year survival rate in BTG1 positive group was higher than that in BTG1 negative group, the difference of survival curves in BIG1 positive and negative patients were statistically significant(P < 0.05).

ConclusionsDetection of BTG1 expression may be useful in predicting prognosis of NSCLC.BTG1-positive patients have a better prognosis.