Multivariate regression analysis of the risk factors of No.8p lymph node metastasis and prognosis in patients with gastric cancer

ObjectiveTo analyze the risk factors of No.8p lymph metastasis and their effects on long-term prognosis in patients with gastric cancer.

MethodsThe clinical data of 106 advanced gastric cancer patients treated with radical operation were analyzed.The patients included 14 cases with No.8p lymph metastasis and 92 cases without No.8p lymph metastasis.The independent risk factors affecting the occurrence of No.8p lymph metastasis were analyzed using multivariate logistic regression analysis, and the effects of No.8p lymph metastasis on the long-term prognosis of patients were analyzed using Cox regression analysis.

ResultsThe incidence rate of No.8p lymph metastasis in 106 patients with gastric cancer was 13.21%.Among the patients with No.8p lymph metastasis, there was no statistical significance in the age, gender, smoking, body mass index and drinking(P>0.05), and the differences of the tumor resection site, serum albumin and hemoglobin content were not statistically significant(P>0.05).However, the No.8p lymph metastasis rates in gastric cancer patients with tumor size ≥ 4 cm, higher TNM staging, combined organ resection and intraoperative blood transfusion were higher(P < 0.05).The results of multivariate logistic regression analysis showed that the female, TNM staging and tumor size were the independent risk factors of No.8p lymph metastasis in gastric cancer patients treated with radical operation.A total of 98 patients(92.45%) were followed up for 22 to 86 months(median time for 43 months), and the 5-year survival rate was 39.80%.The 5-year survival rate in patients with No.8p lymph metastasis(13.33%) was lower than that in patients without No.8p lymph metastasis(44.58%)(P < 0.05).The results of multivariate Cox regression analysis showed that tumor size, TNM staging and No.8p lymph metastasis were the independent factors affecting the prognosis of patients(P < 0.01).

ConclusionsThe sex, TNM staging and tumor size are the independent risk factors of No.8p lymph metastasis in advanced gastric cancer patients.