ObjectiveTo study the value of the serum antithrombin-Ⅲ(AT-Ⅲ) combined with modified CT severity index(MCTSI) in the evaluation of severity and prognosis of patients with acute pancreatitis(AP).
MethodsOne hundred and twenty-four AP patients were divided into the MAP group(38 cases), MSAP group(46 cases) and SAP group(40 cases) according to the severity of the disease, and the survival group(110 cases) and death group(14 cases) according to the prognosis.The serum levels of AT-Ⅲ and MCTSI scores among the groups were compared.The value of serum AT-Ⅲ combined with MCTSI in the diagnosis of SAP and predicting the death in patients with AP were analyzed using the ROC curve.
ResultsThe differences of the serum levels of AT-Ⅲ and MCTSI scores among different disease severity of AP patients were statistically significant(P < 0.01).With the severity of disease increasing, the serum levels of AT-Ⅲ decreased, and the MCTSI scores increased(P < 0.01).The serum level of AT-Ⅲ in death group was significantly lower than that in survival group(P < 0.01), while the MCTSI score was significantly higher than that in survival group(P < 0.01).The AUC, sensitivity and specific degrees of serum AT-Ⅲ combined with MCTSI in the evaluation of AP severity and predicting of death in patients with AP were superior to single detection.
ConclusionsThe serum AT-Ⅲ combined with MCTSI in the assessment of disease severity and prognosis of patients with AP has a higher clinical value.
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