Correlation between S100A12/RAGE/NF-kB inflammatory signal pathway and severity of acute cerebral infarction

ObjectiveTo observe the dynamic changes of S100 calcium binding protein A12(S100A12), receptor for advanced glycation end products(RAGE) and nuclear factor κB(NF-κB) in patients with acute cerebral infarction, and analyze the correlation between them and severity of cerebral infarction.

MethodsEighty-two patients with acute cerebral infarction were set as the observation group.On the 1 d, 3 d and 7 d after admission, the NIHSS scores in the observation group were evaluated, the serum levels of S100A12, RAGE and NF-κB were detected using ELISA, and the correlation between the above indexes and NIHSS score was analyzed.Eighty-five patients without cerebrovascular disease were set as the control group, and the serum levels of S100A12, RAGE, NF-κB were detected on the first day after admission.

ResultsThe serum levels of S100A12, RAGE and NF-κB in observation group on the 1 d, 3 d and 7 d were significantly higher than those in control group(P < 0.01).The levels of S100A12, RAGE and NF-κB was highest on the 1 d(P < 0.05 to P < 0.01), and tbe differences of which between 3 d and 7 d were not statistically significant(P>0.05).The results of correlation analysis indicated that the serum levels of S100A12, RAGE and NF-κB were positively correlated with NIHSS score at each time point(P < 0.05 to P < 0.01).

ConclusionsThe levels of S100A12, RAGE and NF-κB increase, which are related to the severity degree of neurological deficit in patients with acute cerebral infarction.