Effect of malnutrition-inflammation status on the quality of life of elderly hemodialysis patients

ObjectiveTo investigate the relationship between malnutrition-inflammatory status and quality of life in elderly hemodialysis patients.

MethodsOne hundred and three elderly patients with hemodialysis were investigated using malnutrition inflammation score(MIS) combined with kidney disease quality of life short form(KDQOL-SFTM), and the relationship between the results of which and clinical nutritional, inflammatory indicatorsC reactive protein(CRP), interleukin-6(IL-6), body mass index(BMI), albumin(ALB), hemoglobin were analyzed using the correlation and multivariate linear analysis to explore the influencing factors of quality of life.

ResultsThe results of MIS showed that the incidence rate of malnutrition was 83.5%(86/103).The results of ADQOL-SFTM showed that the score of kidney disease-targeted areas(KDTA) was(52.86±9.65), and the score of short form health survey questionnaire 36(SF-36) was(48.74±16.32).The results of correlation analysis showed that the SF-36 score was positively correlated with BMI score(P < 0.01), and negatively correlated with the scores of CRP, IL-6 and MIS(P < 0.05 to P < 0.01).The KDTA score was positively correlated with ALB score(P < 0.01), and negatively correlated with the scores of CRP and age(P < 0.01 and P < 0.05).The results of multiple linear regression analysis showed that the SF-36 score increased, and the scores of IL-6 and MIS decreased with the increasing of BMI.With the decreasing of CRP, the score of ALB increased, and the total KDTA score increased(P < 0.05 to P < 0.01).

ConclusionsThe incidence rate of malnutrition in elderly hemodialysis patients is higher, and the quality of life is lower.The BMI, IL-6 and MIS are important influencing factors of SF-36, and the CRP and ALB are important influencing factors of KDTA.Correcting the state of malnutrition and inflammation is helpful to improve the quality of life of patients.