Clinical significance of albumin in improving coagulation function and serum protein in premature infants

ObjectiveTo explore the clinical significance of albumin in improving coagulation function and serum protein of premature infants.

MethodsOne hundred premature infants were divided into the combined group and control group according to the random number table method.The control group was treated with peripheral vein nutrition combined with early micro enteral feeding, and the combined group was treated with albumin based on the control group.The nutritional recovery of preterm infants was compared between two groups, and the indicators of coagulation function between two goups after treatment were compared.The serum levels of total protein, hemoglobin and albumin in two groups before and after treatment were observed.The blood glucose, urea nitrogen and total bilirubin levels before and after treatment were compared between two groups, and the feeding tolerance and complications in two groups were analyzed.

ResultsThe time of the body mass recovering to normal and feeding time as needed in combined group were shorter than those in control group, and the daily increasing of body mass in combined group was higher than that in control group(P < 0.01).After treatment, the levels of APTT, PT and TT in combined group were lower than those in control group, and the FIB level in combined group was higher than that in control group(P < 0.01).Before treatment, the differences of the serum levels of total protein, hemoglobin, albumin, blood glucose, urea nitrogen and total bilirubin were not statistically significant between two groups(P>0.05).After treatment, the serum levels of total protein, blood glucose, urea nitrogen and total bilirubin in combined group were higher than those in control group(P < 0.01), the differences of the levels of hemoglobin and albumin between two groups were not statistically significant(P>0.05), and there was no statistical significance in the blood glucose level between before and after treatment in control group(P>0.05).The serum levels of blood glucose in combined group, and urea nitrogen, total bilirubin, blood glucose, urea nitrogen and total bilirubin in two groups after treatment were higher than those before treatment(P < 0.05 to P < 0.01).The tolerance rate of premature infant feeding in combined group was higher than that in control group, and the total incidence rate of complications in combined group was lower than that in control group(P < 0.01 and P < 0.05).

ConclusionsAlbumin has a significant clinical effect on improving the coagulation function and serum protein of preterm infants.It can significantly improve the blood glucose, urea nitrogen and total bilirubin levels of preterm infants, and has fewer complications.