Predictive value of the ratio of LAP to serum ApoB/ApoA1 in polycysticovarian syndrome combined with metabolic syndrome

ObjectiveTo explore and compare the predictive value of the ratio of lipid accumulation product(LAP) to serum ApoB/ApoA1 in polycysticovarian syndrome(PCOS) combined with metabolic syndrome(MS).

MethodsA total of 136 PCOS patients were selected as the research objects.According to the diagnosis of MS, patients were divided into the combined group and non-combined group.Physical indexes, glycolipid metabolism indexes and endocrine related indexes were collected to calculate the ratio of LAP to serum ApoB/ApoA1.The differences between the two groups and the correlation between LAP, serum ApoB/ApoA1 ratio and other indexes were compared.The ROC curve was used to analyze the predictive diagnostic value of LAP and serum ApoB/ApoA1 ratio for PCOS combined with MS.

ResultsThere was no significant difference in age, LH, PRL, E2 and TC between the two groups(P>0.05).The WC, SBP, DBP, BMI, FSH, T, FPG, FINS, HOMA-IR, TG, LDL-C, ApoB/ApoA1 and LAP in the combined group were higher than those in the non-combined group, and the HDL-C was lower than that in the non-combined group(P < 0.01).The results of correlation analysis showed that ApoB/ApoA1 and LAP were positively correlated with age, WC, SBP, DBP, BMI, FSH, PRL, E2, T, FPG, FINS, HOMA-IR, TC, TG and LDL-C(P < 0.01).The AUC of ApoB/ApoA1 and LAP were 0.780 and 0.845 respectively.The specificity and sensitivity of ApoB/ApoA1 were 50.0% and 100.0%, respectively, and the specificity and sensitivity of LAP were 67.5% and 99.0%, respectively.The AUC of PCOS combined with MS was 0.818, the specificity and sensitivity were 55.0% and 100.0%, respectively.The prediction efficiency was lower than LAP and higher than ApoB/ApoA1.

ConclusionsThe ratio of LAP and serum ApoB/ApoA1 can be used as an important index to predict the diagnosis of PCOS combined with MS, and the reliability of LAP in the diagnosis of PCOS combined with MS is higher than ApoB/ApoA1.