Changes and clinical significance of the levels of inflammatory factors and coagulation factors in patients with endometriosis

ObjectiveTo detect the levels of inflammatory factors and coagulation factors in peripheral blood of patients with endometriosis, and further explore the role of inflammatory factors and coagulation factors in endometriosis and its clinical diagnostic value.

MethodsA total of 216 patients diagnosed as stage Ⅲ and Ⅳ endometriosis after surgery and 117 patients with benign cysts diagnosed by pathology were divided into the endometriosis group and control group, respectively.The general clinical data, levels of inflammatory factors, coagulation factors and cancer antigen 125(CA125) in peripheral blood were compared between two groups.The levels of inflammatory and coagulation factors were compared among patients of different stages.The ROC curve was used to evaluate the diagnostic value of CA125 and fibrinogen level(FIB) alone or combined in patients with stage Ⅲ and Ⅳ.

ResultsThe number of pregnancies and births in endometriosis group were higher than those in control group(P < 0.01).The neutrophil lymphocyte ratio(NLR), platelet lymphocyte ratio(PLR), D-dimer(D-D), C-reactive protein(CRP) and erythrocyte sedimentation rate in endometriosis group were higher than those in control group(P < 0.01).The prothrombin time(PT) and thrombin time(TT) in endometriosis group were shorter than those in control group(P < 0.01), and the levels of FIB and CA125 levels in endometriosis group were higher than those in control group(P < 0.01).Compared with stage Ⅲ group, the levels of PLT and PLR were higher, the PT time was shorter, and the FIB was higher in stage Ⅳ group(P < 0.05 to P < 0.01).The differences of the levels of NLR and D-D, APTT and TT between stage Ⅲ group and stage Ⅳ group were not statistically significant(P>0.05).In the diagnosis of endometriosis, the sensitivity of CA125 combined with FIB was 84.6%, the sensitivity of CA125 was 81.9%, the sensitivity of FIB was 50.4%.

ConclusionsThe expression of inflammatory and coagulation factors is abnormal in the endometriosis group, and which is correlated with the stage of endometriosis.The combined detection of CA125 and FIB can improve the sensitivity of the diagnosis of endometriosis.