Comparative analysis of the bacterial distribution and inflammatory markers of bloodstream infection between hematologic patients and intensive care patients

ObjectiveTo explore the differences of the bacterial species, drug resistance and inflammatory markers such as C-reactive protein(CRP), procalcitonin(PCT) and white blood cell count(WBC) between hematologic patients and intensive care patients.

MethodsIn the contemporaneous area, the patients with hematological disease and intensive care patients with positive blood culture were divided into the hematological disease group(HDG) and non-hematological disease group(NHICG), respectivlely, and the patients with hematological disease and intensive care patients with negatvie blood culture were divided into the control group(HDCG) and negative control group(NCG), respectively.The levels of the PCT, CRP and WBC in all cases were detected.The patients with hematologic diseases were subdivided into the acute lymphoblastic leukemia group(ALLG group), acute lymphoblastic leukemia group(AMLG group) and aplastic anemia group(AAG group).The differences of the blood culture identification, drug sensitivity test results and inflammatory indexes among groups and subgroups were observed.

ResultsComparison of the total positive rates between HDG and NHICG groups: the top three were coagulase-negative staphylococcus, Klebsiella pneumoniae and subspecies, and Escherichia coli, with only different sequencing.The bacteria in two groups were mainly Gram-negative bacteria.The positive rate, number of drug-resistant strains and bacteria in the top of drug-resistant rate were still roughly the same in the HDG and NHICG groups.Except NLR, the differences of other inflammatory indicators among HDG, HDCG, NHICG and NCG groups were statistically significant(P < 0.01).The differences of all inflammatory indicators among ALLG, AMLG and AAG subgroups were not statistically significant(P>0.05).

ConclusionsThe detection rate and drug resistance rate of bloodstream infection bacteria in patients with hematological diseases and severe patients are relatively concentrated.The types and drug-resistant types of bloodstream infection bacteria in the three common blood diseases are roughly the same.The methicillin-resistant coagulase-negative staphylococcus has become a common Gram-positive pathogenic bacteria and multi-drug resistant bacteria in blood patients and severe patients.The combination of PCT, CRP, WBC and other inflammatory markers is of certain significance for the rapid and effective identification of bloodstream infection.