Study on the relationship between sleep disturbance and ecological executive function after acute ischemic stroke

ObjectiveTo observe the correlation between sleep disturbance and ecological executive function after acute ischemic stroke.

MethodsA total of 103 patients with acute ischemic stroke were selected and divided into sleep disturbance group and normal sleep group according to the Pittsburgh sleep quality index scores.Polysomnography(PSG) and ecological behavior rating inventory of executive function-adult version(BRIEF-A) were used to evaluate sleep quality and executive function, and the difference of which between the two groups was compared.Multiple stepwise regression analysis was applied to explore the correlation between PSG sleep parameters and BRIEF-A scores.

ResultsThe total score(GEC), scores of metacognition index(MI) and its factors(organization, planning, working memory, task initiation, task monitoring), and scores of behavior regulation index(BRI) and its factors(conversion, inhibition, self-monitoring, emotional control) of BRIEF-A in sleep disturbance group were higher than those in normal sleep group(P < 0.05 to P < 0.01).Compared with the normal sleep group, the total sleep time(TST) was shortened, the sleep efficiency(SE) decreased, the non-rapid eye movement sleep phase 3(NREM3) decreased, and the rapid eye movement sleep latency(RL), sleep latency(SL), wake-up time after falling asleep, proportion of non-rapid eye movement sleep phase 1 to total sleep time, and proportion of rapid eye movement sleep phase to total sleep time(REM%) increased in the sleep disturbance group(P < 0.05 to P < 0.01).Multiple stepwise linear regression analysis showed that GEC, MI, BRI were negatively correlated with TST and SE(P < 0.05 to P < 0.01), GEC and MI were negatively correlated with the proportion of NREM3 to total sleep time(P < 0.01 and P < 0.05), GEC and MI were significantly positively correlated with REM%(P < 0.01), and GEC was significantly positively correlated with REM%(P < 0.01).

ConclusionsPatients with sleep disturbance after acute ischemic stroke have ecological executive function compared with those without sleep disturbance, which are related to sleep parameters in the sleep-wake cycle.