Comparison of efficacy of different adjuvant therapies for stage Ⅰb1-Ⅱa2 cervical cancer after radical surgery

ObjectiveTo investigate the adverse reactions and long-term effects of different adjuvant therapies for stageⅠb1-Ⅱa2 cervical cancer with intermediate and high risk factors after radical surgery.

MethodsA total of 128 patients with stageⅠb1-Ⅱa2 cervical cancer were analyzed retrospectively, 40 patients of which received combination of surgery, adjuvant radiotherapy and cisplatin(DDP) weekly(radiotherapy combined with DDP group), and 88 patients of which received combination of surgery, adjuvant radiotherapy, and paclitaxel combined with ODP(TP) regimen(radiotherapy combined with TP group).The adverse reactions and long-term effects of the two groups were compared.

ResultsCompared with radiotherapy combined with TP group, the level of grade Ⅲ-Ⅳ leucocytes decreased in radiotherapy combined with DDP group(P < 0.01);the level of grade Ⅲ-Ⅳ hemachrome and grade Ⅲ-Ⅳ platelet, and incidence of grade Ⅲ-Ⅳ vomiting and grade Ⅲ-Ⅳ adiation proctitis in radiotherapy combined with DDP group reduced, but the differences of which were not statistically significant(P>0.05).There was no significant difference in the follow-up time, rate of recurrence and 5-year survival rate between the two groups(P>0.05).

ConclusionsThe weekly radiotherapy combined with DDP therapy for stageⅠb1-Ⅱa2 cervical cancer patients with intermediate and high risk factors after radical surgery has little adverse reactions and good long-term efficacy.