Application effects of three different postoperative analgesic regimens in laparoscopic total hysterectomy

ObjectiveTo compare the clinical effects of three different postoperative analgesic regimens in laparoscopic total hysterectomy.

MethodsNinety patients scheduled by laparoscopic total hysterectomy were randomly divided into the dezocine combined with tramadol group(DT group), dezocine combined with flurbiprofen axetil group(DF group) and dezocine combined with sufentanil group(DS group)(30 cases in each group). The DT, DF and DS groups were treated with 0.5 mg/kg dezocine+10 mg/kg tramadol, 0.5 mg/kg dezocine+3 mg/kg flurbiprofen axetil and 0.5 mg/kg dezocine+1 μg/kg sufentanil for postoperative patient controlled intravenous analgesia(PCIA), respectively. The VAS score ≤3 points was maintained.If VAS score > 3 points, the 0.1 mg/kg dizocine was added in a single dose. The Ramsay sedation score and BCS comfort score among three groups were recorded after 2 h, 4 h, 8 h, 12 h and 24 h of surgery. The dose of dezocine, dose of additional dezocine, number of PCIA, postoperative bowel sounds recovery time, first anal exhaust time, first time out of bed activity, nausea, vomiting, bloating and dizziness among three groups were recorded.

ResultsCompared with the DT group and DS group, the postoperative bowel sound recovery time, first anal exhaust time and first time of getting out of bed activity were significantly shortened(P < 0.05), and the postoperative nausea, abdominal distension and dizziness significantly reduced in the DF group(P < 0.05). There was no statistical significance in Ramsay sedation score and BCS comfort score among three groups after 2 h, 4 h, 8 h, 12 h and 24 h of surgery, and the differences of the dose of dezocine, dose of additional dezocine and number of PCIA were not statistically significant(P > 0.05).

ConclusionsDezoxin combined with flurbiprofen axetil is more beneficial to the recovery of gastrointestinal function on the basis of satisfying postoperative analgesia.