ObjectiveTo observe the correlation between the serum levels of CD64, interleukin-6(IL-6), platelet distribution width(PDW) and the distribution characteristics of pathogenic bacteria and infection prognosis in patients with acute myeloid leukemia complicated with infection.
MethodsNinety patients with acute myeloid leukemia complicated with infection were selected as the study group, and 90 patients with acute myeloid leukemia without infection were selected as the control group. The serum levels of CD64, IL-6 and PDW in the two groups, the distribution characteristics of pathogenic bacteria in the study group, and the serum levels of the above indicators in patients with different infection type and infection prognosis were analyzed. The influencing factors of infection prognosis and death in patients with acute myeloid leukemia complicated with infection was explored, and the predictive value of the above serum indicators for the infection prognosis and death in patients with acute myeloid leukemia and infection was analyzed.
ResultsThe serum levels of CD64, IL-6 and PDW in study group were higher than those in control group(P < 0.05). One hundred and eighteen strains of pathogenic bacteria were isolated from 90 patients in the study group, which were main Gram-negative bacteria, with a total of 78 strains(66.10%), followed by 30 strains(25.42%) of Gram-positive bacteria and 10 strains(8.47%) of fungi. In the study group, the serum levels of CD64, IL-6 and PDW in patients with Gram-negative bacteria infection were higher than those in patients with Gram-positive bacteria and fungi infection, the serum levels of the above indicators in patients with Gram-positive bacteria infection were higher than those in patients with fungi infection, and the serum levels of the above indicators in dead patients were higher than those in survival patients(P < 0.05). Logistic regression analysis showed that serum CD64, IL-6 and PDW were important risk factors for prognosis and death of patients with acute myeloid leukemia complicated with infection(P < 0.01). The ROC curve showed that the specificity and sensitivity of combination of serum CD64, IL-6 and PDW to predict the prognosis and death of patients with acute myeloid leukemia complicated with infection were 82.43% and 81.25%, respectively.
ConclusionsThe serum levels of CD64, IL-6 and PDW in patients with acute myeloid leukemia complicated with infection are significantly increased, and the expressions are closely related to the distribution characteristics of pathogenic bacteria and infection prognosis.
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