Effect of butylphthalide injection on acute cerebral infarction and its influence on serum N-terminal pro-B-type natriuretic peptide and homocysteine level

ObjectiveTo observe the curative effect of butylphthalide injection in the treatment of acute cerebral infarction, and to explore its influence on the levels of serum N-terminal pro-B-type natriuretic peptide(NT-proBNP) and homocysteine(Hcy).

MethodsA total of 70 patients with acute cerebral infarction were randomly divided into observation group and control group, 35 cases in each group. The patients were given conventional treatment, and the observation group was additionally given butylphthalide sodium chloride injection 100 mL each time, intravenous drip, twice a day, continuous injection for 10-14 days. The clinical efficacies of two groups were compared, and the levels of serum NT-proBNP and Hcy were measured before and after treatment. The neurological deficits of the two groups were scored by National Institutes of Health stroke scale(NIHSS) before and after treatment, and the neurological status of the patients was evaluated by modified Rankin scale(mRS).

ResultsThe total treatment efficiency in the observation group was 94.29%(33/35), which was significantly better than 71.43%(25/35) in the control group(P < 0.01). Before treatment, there was no significant difference in NIHSS score, mRS score and serum NT-proBNP and Hcy levels between the two groups(P > 0.05). After treatment, NIHSS score, mRS score, NT-proBNP and Hcy levels in the observation group were lower than those before treatment(P < 0.05), while NIHSS score, NT-proBNP and Hcy levels in the observation group were significantly lower than those in the control group(P < 0.01).

ConclusionsButylphthalide injection can improve the neurological deficit of acute cerebral infarction and reduce the serum NT-proBNP and Hcy levels.