Retrospective controlled study on the clinical effect of albumin and plasma volume expansion in the treatment of early onset preeclampsia

ObjectiveTo investigate the effect of albumin and plasma volume expansion in the treatment of early onset preeclampsia.

MethodsThe clinical data of 120 singleton pregnant women with early onset preeclampsia were analyzed retrospectively, and divided into plasma group(volume expanded with plasma, 40 cases), albumin group(volume expanded with albumin, 40 cases)and control group(no volume expanded, 40 cases). The expectant pregnant time, adverse perinatal outcome and incidence of maternal complications were compared among the three groups.

ResultsThe gestational week of delivery in volume expansion group(albumin group and plasma group)was longer than that in control group(P < 0.05), and the incidence of fetal growth restriction was lower than those in control group(P < 0.05). The incidence of placental abruption and postpartum hemorrhage in plasma group was lower than that in control group(P < 0.05), and the incidence of renal function injury in plasma group was lower than that in albumin group(P < 0.05).

ConclusionsThe efficacy of volume expansion therapy with albumin and plasma in the treatment of early onset preeclampsia is significant, which can prolong gestational week and improve perinatal outcome without increasing maternal complications.