Effect of growth hormone combined with antagonist regimen on pregnancy outcomes in IVF-ET patients with low ovarian response

ObjectiveTo explore the effects of the growth hormone(GH) combined with antagonist regimen on pregnancy outcome in poor ovarian response(POR) patients treated with fertilization-embryo transfer(IVF-ET) in vitro.

MethodsThe clinical data of 176 POR patients treated with IVF-ET were retrospectively analyzed, and the patients were divided into the GH group(GH⁺ group, 84 cases) and non-GH group(GH^- group, 92 cases) according to whether GH was used or not. The egg number, MⅡ egg rate, normal fertilization rate, day 3 transferable embryo rate, day 3 high quality embryo rate, blastocyst formation rate, high quality blastocyst rate, clinical pregnancy rate and implantation rate were compared between two groups.

ResultsThe egg number, daybryo rate, blastocyst formation rate, clinical pregnancy rate and implantation rate in GH⁺ group were higher than those in GH^- group(P < 0.05 to P < 0.01).The differences of MⅡ egg rate, normal fertilization rate, high quality embryo rate on day 3 and high quality blastocyst rate between two groups were not statistically significant(P > 0.05).

ConclusionsThe GH combined antagonist regimen is helpful for improving IVF-ET pregnancy outcomes in the POR patients.