Homology analysis of carbapenem-resistant Acinetobacter baumannii in ICU

ObjectiveTo investigate the drug resistance of carbapenem-resistant Acinetobacter baumannii(CRAB) in ICU of a hospital, and analyze the homology of the strains, so as to provide reference for the prevention and control measures of nosocomial infection.

MethodsThirty CRAB strains isolated from ICU of a hospital from April to October 2017 were collected for drug sensitivity test, and their homology was analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS).

ResultsThe resistance rate of 30 CRAB strains to cefotetan, ceftriaxone, ceftazidime, cefepime and ciprofloxacin was 100.0%, and to levofloxacin was 73.3%.MALDI-TOF MS analysis showed that 30 CRAB strains were classified into three clusters, type Ⅰ(28 strains), type Ⅱ(1 strain) and type Ⅲ(1 strain), among which type Ⅰ was classified into type Ⅰa(26 strains), type Ⅰb(1 strain) and typeⅠc(1 strain), and 12 strains of type Ⅰa were isolated from August 2 to August 30 in 2017.

ConclusionsIn April to October 2017, the main type of CRAB isolated from ICU of a hospital is type Ⅰa, and there is a trend of aggregation of type Ⅰa CRAB infection cases in August.