Study on the correlation between the expression levels of IP-10 and CXCR3 in diffuse large B-cell lymphoma tissue, and cell proliferation, invasion and drug resistance proteins expression

ObjectiveTo study the correlation between the expression levels of recombinant human interferon inducible protein-10(IP-10) and CXC subfamily chemokine receptor 3(CXCR3) in diffuse large B-cell lymphoma(DLBCL) tissue, and cell proliferation, invasion and drug resistance proteins expression.

MethodsSixty DLBCL patients and 30 patients with reactive lymph node hyperplasia were divided into the DLBCL group and control group, respectively.The levels of IP-10, CXCR3, cell proliferation indicator Ki67, proliferating cell nuclear antigen(PCNA), leukocyte differentiation antigen 44V6(CD44V6), matrix metalloproteinase-9(MMP-9), P-glycoprotein(P-gp) and multidrug resistance associated protein 1(MRP1) were compared between two groups.

ResultsThe expression levels of IP-10, CXCR3, Ki67, PCNA, CD44V6, MMP-9, P-gp and MRP1 in DLBCL group were significantly higher than those in control group(P < 0.01).In DLBCL group, the expression levels of IP-10 and CXCR3 were correlated with the expression of cell proliferation-related proteins(Ki67 and PCNA) and tumor invasion-related proteins(PCNA and CD44V6)(P < 0.05 to P < 0.01), and not correlated with the expression of cell drug-resistance-related proteins(P-gp and MRP1)(P>0.05).

ConclusionsIn DLBCL, the expression levels of IP-10 and CXCR3 increase significantly.The expression of IP-10 and CXCR3 may increase the proliferation and invasion of tumor cells, which may not be related to the drug resistance of tumor cells.