ObjectiveTo explore the clinical value of neutrophil to lymphocyte ratio(NLR)and interleukin(IL)-6 level in peripheral blood in predicting the recurrence of chronic rhino sinusitis(CRS)after endoscopic sinus surgery.
MethodsEighty-seven patients with CRS treated with endoscopic sinus surgery were divided into the postoperative recurrence group(30 cases)and non-recurrence group(57 cases)according to the disease recurrence after surgery, and 40 healthy people were set as the control group at the same period.The levels of neutrophils and lymphocytes in peripheral blood in two groups were detected by automatic blood biochemical analyzer to calculate the NLR.Meanwhile, the levels of IL-6 in peripheral blood of each group were detected by enzyme-linked immunosorbent assay.The neutrophil count, lymphocyte count, NLR and IL-6 levels were compared between two groups.The receiver operating characteristic curve was used to analyze the value of single and combined peripheral blood NLR and IL-6 detection in predicting the recurrence of CRS after endoscopic sinus surgery.
ResultsThe neutrophil count, NLR and IL-6 levels in CRS group were significantly higher than those in control group(P < 0.01), while the lymphocyte count in CRS group was significantly lower than that in control group(P < 0.01).The neutrophil count, NLR and IL-6 levels in recurrence group were significantly higher than those in non-recurrence group(P < 0.01), while the lymphocyte count in recurrence group was significantly lower than that in non-recurrence group(P < 0.01).The sensitivity, specificity and area under the curve of the combined detection of peripheral blood NLR and IL-6 were significantly better than those of single detection of peripheral blood NLR and IL-6(P < 0.01).
ConclusionsThe combined detection of NLR and IL-6 in peripheral blood has good clinical values to predict the recurrence of CRS after endoscopic sinus surgery.
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