Study on the protective effects of ulinastatin combined with Shenfu injection on the myocardial injury in severe acute pancreatitis

ObjectiveTo investigate the protective effects of ulinastatin combined with Shenfu injection on the myocardial injury in patients with severe acute pancreatitis.

MethodsNinety patients with severe acute pancreatitis complicated with myocardial injury were randomly divided into the treatment group and control group(45 cases in each group).The control group was treated with conventional therapy combined with ulinastatin, the treatment group was additionally treated with ulinastatin and shenfu injection on the basis of conventional treatment, and the whole course of treatment was 10 days.The clinical symptom recovery time, acute physiology and chronic health score(APACHE Ⅱ) and bedside index of severity in acute pancreatitis(BISAP) in two groups were observed.The fasting venous blood was extracted from the patients, and the serum levels of N-terminal pro-B type brain natriuretic peptide(NT-proBNP), troponin I(cTnI) and creatine kinase MB isoenzyme(CK-MB) in two groups were determined before treatment.After 5 d and 10 d of treatment, the differences of biochemical indexes between two groups were compared.

ResultsThe recovery time of abdominal pain, abdominal distention, exhaust, defecation and bowel sounds in treatment group were shorter than those in control group after treatment(P < 0.05).On day 10 after treatment, all indexes in two groups were lower than those before treatment(P < 0.01), and the serum levels of NT-proBNP and cTnI in treatment group were lower than those in control group(P < 0.05).The serum levels of cTnI in treatment group was lower than that in control group after 5 and 10 days of treatment(P < 0.05).The serum level of CK-MB in treatment group was lower than that in control group after 5 days of treatment(P < 0.05).Compared with before treatment, the BISAP score and APACHE Ⅱ score in two groups decreased after treatment(P < 0.05).

ConclusionsThe ulinastatin combined with Shenfu injection has a good protective effect on myocardial injury in patients with severe acute pancreatitis, can improve the clinical symptoms of patients, regulate the levels of cTnI, CK-MB and NT-proBNP, and has clinical application value.