Study on the diagnostic and prognostic evaluation value of heparin-binding protein in community-acquired pneumonia

ObjectiveTo evaluate the diagnostic and prognosis value of heparin-binding protein(HBP) in community-acquired pneumonia(CAP) patients.

MethodsAccording to the pneumonia severity index(PSI) score, 115 CAP patients were divided into the low-risk group(25 cases with < 90 points), middle-risk group(43 cases with 90-130 points) and high-risk group(47 cases with>130 points).Forty-two healthy people were set as the control group.The heparin-binding protein(HBP) in all cases were tested after admission, which were compared and analyzed with the procalcitonin(PCT) and white blood cell(WBC).The ROC curve was used to analyze the diagnostic efficacy of each index to CAP.The correlation between HBP index and PSI score was analyzed, the number of death and survival cases in the high risk group were counted, and which was compared with HBP index.

ResultsThe HBP level in high-risk group(187.05±48.96) ng/mL were higher than that in middle-risk group(16.80±5.34) ng/mL, low-risk group(13.49±4.87)ng/mL and control group(5.34±1.50) ng/mL, the differences of HBP level between high-risk group and other groups were statistically significant(P < 0.05), and the difference of HBP level between middle and low risk groups was not statistically significant(P>0.05).The diagnostic sensitivity and specificity of heparin binding protein were 100.0% and 96.7%, respectively.The HBP indicators were positively correlated with PSI(P < 0.05).In the high-risk group, the HBP levels in death group(197.65±46.75) ng/mL was significantly higher than that in survival group(125.43±23.76) ng/mL(P < 0.01).

ConclusionsThe HBP is of auxiliary value in the diagnosis of CAP(especially in high-risk group), so it can be used to evaluate the severity of the disease.It is also one of the reference index for the prognosis evaluation of CAP.