Objective To investigate the expressions of serum homocysteine(Hcy), folic acid(FA) and vitamin B12(VitB12) in patients with preeclampsia and their correlation with the severity of preeclampsia.
Methods Sixty patients with preeclampsia were selected as the observation group, and divided into severe PE group(n=30) and PE group(n=30) according to the severity of the disease, and 30 pregnant women for prenatal checkups at the same period were set as the healthy control group.The serum levels of Hcy, FA and VitB12 in the three groups were compared.The abnormal rates of Hcy, FA and VitB12 in the severe PE group and PE group were analyzed.The correlation of Hcy, FA and VitB12 levels in PE group, and the correlation of Hcy, FA and VitB12 levels with the severity of PE disease and perinatal outcome were analyzed.
Results The level of Hcy in the severe PE group and PE group was higher than that in the healthy control group(P < 0.05), and the level of FA and VitB12 was lower than that in the healthy control group(P < 0.05).The level of Hcy in the severe PE group was higher than that in the PE group(P < 0.05), and the level of FA and VitB12 was lower than that in the PE group(P < 0.05).The abnormal rate of Hcy and FA in the severe PE group was lower than that in the PE group(P < 0.05 and P < 0.01), and there was no significant difference in the abnormal rate of VitB12 between the two groups(P>0.05).The results of Spearman rank correlation analysis showed that the level of Hcy was negatively correlated with the level of FA(P < 0.05), the level of FA was positively correlated with the level of VitB12 in the PE group(P < 0.05), and the level of Hcy was not significantly correlated with the level of VitB12(P>0.05);the level of Hcy was positively correlated with the severity of preeclampsia disease(P < 0.05), the level of FA was negatively correlated with the severity of preeclampsia disease(P < 0.05), and the level of VitB12 was not significantly correlated with the severity of preeclampsia disease(P>0.05);the level of Hcy was negatively correlated with the Apgar score(P < 0.05), the level of FA was positively correlated with the Apgar score(P < 0.05), and the level of VitB12 was not significantly correlated with the Apgar score(P>0.05).
Conclusions The serum level of Hcy is higher, and the level of FA is lower with the accelerating severity of preeclampsia.There is a positive correlation between FA level and VitB12 level, and a negative correlation between FA level and Hcy level.
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